Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It is one of the most common, lifelong disorders in both the US and Europe affecting approximately 1 % of the general population. The CD prevalence in developing countries is less clear, although occasional data suggest that CD prevalence could be high in Northern Africa and Middle East countries. In these areas, untreated CD may contribute to childhood mortality by worsening the vicious circle of diarrhea-malnutrition. The determination of anti-transglutaminase (tTG) antibodies (Ab) is considered a sensitive tool for detecting atypical and silent forms of CD. Aims of the study:- (1) to investigate for the prevalence of CD among children in Egypt, (2) to describe the main presenting symptoms of CD in the positive group. Methods: 1500 case was picked out from Abu El Reish hospital outpatient clinic. The screening test was serum class A anti-tTG Ab. Samples showing anti-tTG less than 0.5 U were further analyzed for IgG class anti-tTG and total IgA level (to rule out IgA deficiency). Serum antiendomysium Ab (EMA) determination was performed in subjects that tested positive for anti-tTG IgA Ab. Small intestinal biopsy was recommended to subjects showing IgA anti-tTG and EMA positivity or IgA deficiency plus IgG anti-tTG positivity. Results: Showed, prevalence of affection in the selected group was 1.4%, with a higher incidence of affection in females than males, and main presenting symptoms to be failure to thrive.Conclusion: These results indicate that CD in the Egyptian pediatric population is as frequent as in Europe and North America.