Cisplatinum is one of the most effective antineoplastic drugs used in the treatment of ovarian, testicular and head and neck tumors, but it has undesirable toxic effects on the liver at high doses. The present study was designed to detect the toxic effect of the cisplatinum on the liver in the adult albino rats and the possible protective role of vitamin E in prevention of such toxicity. Thirty two rats were used in the current study. They were divided into three groups (control group, sham control group treated with vitamin E, cisplatinum treated group and vitamin E and cisplatinum treated group). Each group was subdivided into two subgroups ("1" and "2") according to time of scarification (after 16 hour in subgroup "1" and after 3 weeks in group "2"). The possible mechanism of cisplatinum toxicity in the liver was due to affection of oxidant-antioxidant system in the hepatocytes of rats and this explained the partial improvement with vitamin E administration.