Type 2 diabetes mellitus (DM) is associated with an increased riskof peripheral vascular disease (PVD), but within the diabetic population the relationship between various risk factors of atherosclerosis and PVD has not been clearly defined. Conventional and genetic risk factors have been reported to play a role in the pathogenesis of vascular disease, but do not explain the lower burden of cardiac and PVD. So, the relationship of lower extremity arterial disease to the different risk factors foratherosclerosis in type 2 diabetes mellitus is a matter of continuinginvestigation. The inflammatory marker C-reactive protein (CRP)predicts risk of myocardial infarction and thromboembolic stroke,whether increased levels of CRP are associated with the evelopment of symptomatic PVD is unknown.We studied 60 cases all were subjected to clinical examination andlaboratory work-up in the form of C-reactive protein and lipid profile (total cholesterol, triglycerides, high density and low density lipoproteins). Statistical analysis was done to demonstrate any relation between diabetic macro-vascular complications and those clinica l and laboratory parameters.CRP was higher in diabetic patients with vascular complicationswhen compared to those without vascular complications. Also the lipid profile is statistically higher in the patients with diabetic macro-vascular complications compared to those without.