Rational and backgroundSpontaneous pre-labour rupture of membranes (SPROM) at term is one of the most common complications of pregnancy. It is an important cause of perinatal morbidity and mortality, particularly because it is associated with a latency period from membrane rupture to delivery.aim of workcompare the efficacy and safety of immediate induction of labour with intravaginal misoprostol, with those who will have induction of labour with intravenous oxytocin infusion after an expectant period of 12 hours, at term in patients with PROM and a favourable cervixPatients and methodsRandomized control study of 150 women who had either immediate induction of labour with intravaginal misoprostol tablets, or delayed induction with intravenous oxytocin infusion after an expectant period of 12 hours, at helwan general Hospital. The outcome of labour was compared in the two groups using the Z test and Chi square test, while, p-value of less than 0.05 was taken assignificant. The odds ratio (OR) and 95% confidence interval were also determined where appropriate.ResultsImmediate induction of labour with intravaginal misoprotol resulted in lower rates of caesarean section and operative vaginal delivery, with a higher rate of spontaneous vaginal delivery. The duration of latent phase of labour and hospital stay before delivery was statistically significantlyshorter in the immediate induction group. Neonatal and maternal morbidity were insignificant and comparable between the two groups.Conclusion: Immediate induction of labour with intravaginal misoprotol resulted in significantly lower rates of intervention without compromising fetomaternal outcome. We recommend the immediate induction of labour with proper use of intravaginal misoprotol in women with SPROM at term.