Regional anesthesia is considered one of those modalities for pain management either alone or in combination with general anesthesia or even be used for postoperative pain management. In this essay we discuss the history of regional anesthesia application and its importance in wars, also we discuss in another chapter the advantages and disadvantages of application of regional anesthesia in trauma patients. Finally, we discuss different techniques of regional anesthesia application and different methods of identification of nerves to be blocked including the usage of ultrasound which is so promising in this field.