Oesophageal varices are one of the most important complications of livercirrhosis and portal hypertension. Bleeding oesophageal varices is themost common cause of upper GI haemorrhage in Egypt with highmortality rate. Aim of work was to develop a method for prediction of the presence and thesize of varices using non invasive clinical, laboratory, ultrasonographicand Doppler parameters. 200 patients with liver cirrhosis with no history ofvariceal haemorrhage were subjected to complete history taking,thorough clinical examinations, laboratory investigations, abdominalultrasonography and Doppler study of the portal and splenic veins. Upperendoscopy was done classifying patients into 3 groups; patients withoutvarices, patients with small sized varices and patients with large sizedvarices. Using multivariate logistic regression analysis, biphasic andmonophasic hepatic veins flow pattern, bidirectional and Hepatofugalportal vein direction of flow, decreased portal vein velocity and thepresence of ascites were the significant variables for prediction ofpresence of varices. Shrunken liver and low serum albumin were thesignificant variables for prediction of large sized varices.