Introduction. Recent evidence suggests that helicobacter pylori infections play a role in the pathogenesis of a variety of skin diseases. Various mechanisms have been proposed in an attempt to explain the extra intestinal manifestations of H. pylori infections. They are based on the ability of H. pylori to initiate systemic immune response whether humoral or T cell mediated. Vitiligo is a generalized depigmented disorder manifesting as acquired white patches due to loss of melanocytes. Immune dysregulation play an important role in the pathogenesis of vitiligo. So, we may propose that H. pylori may play a role in vitiligo through triggering an immune response. Aim of the Work. To clarify if helicobacter pylori plays a role in the pathogenesis of vitiligo or not. Patients and methods. The study included 40 patients with different types of vitiligo without GIT symptoms as well as 40 healthy volunteers served as control. Anti Helicobacter pylori Igs (IgG, IgA, IgM) was assessed in the serum of vitiligo patients and controls using ELISA Test. Results. An overall anti H. pylori IgG antibody seropositivity of 57.5% (n = 23) was found in vitiligo patients compared with an overall value of 30% (n = 12) for the control group. The difference in seropositivity between patients and controls was statistically significant (P-value = 0.013). An overall anti H. pylori IgA antibody seropositivity of 32.5% (n = 13) was found in vitiligo patients compared with an overall value of 15% (n = 6) for the control group. The difference in seropositivity between patients and controls was not statistically significant (P-value = 0.066). Anti H. pylori IgM antibody seroprevalence of the vitiligo patients and controls was negative. When comparing the IgG level in the patient and control groups, the mean expression level of IgG in the serum of vitiligo patients was higher than in the control serum, and this difference is statistically significant (P Value = 0.041). While the mean expression level of IgA, IgM in the serum of vitiligo patients was higher than in control group but this difference is statistically not significant (P-value= 0.060, 0.580 for IgA, IgM respectively). Conclusion. Increased prevalence of H. pylori infection in association with vitiligo, together with the high level of anti H. pylori IgG in vitiligo patients compared to control are with our concept that H. pylori infection may play a role in the pathogenesis of vitiligo.