Introduction:Liver transplantation has evolved to become the treatment of choice in end stage liver disease. Due to shortage of cadaveric livers and in our country the absence of law and lack of societal acceptance of organ retrieval from brain dead donors resulted in live donation being the main source of livers in patients awaiting transplantation.At the same time the development of the knowledge of segmental and vascular anatomy of the liver contributed very much to liver surgery.Purpose:Liver transplantation is a radiology intensive procedure that involves the pre-operative assessment of donors by multi-detector computed tomography and magnetic resonance cholangiography.Our objective was to evaluate the accuracy of pre-operative assessment of donors by multi-detector computed tomography and magnetic resonance cholangiography.Materials and Methods: This study was composed of 40 donors who underwent right lobectomy for living donor liver transplantation. Preoperative MDCT using a 64-row detector of the liver was done for volumetry of the graft and measurement of the graft to recipient body weight ratio (GRWR) and assessment of the fatty infiltration of the liver as well as MDCT angiography for assessment of the vascular arterial portal and venous anatomy. 3.0 Tesla MRC was performed for assessment of the biliary anatomy.Our gold standard was the intra-operative assessment of the graft weight and vascular anatomy as well as the intra-operative cholangiogram for assessment of the biliary anatomy.Results: The graft size measured preoperatively had a mean weight of 850 ± 136.8gms, while that measured intra-operatively had a mean weight of 885.3 ± 147.9gms, with a mean weight difference of 35.25gms with an accuracy of about 90%.The mean preoperative and post operative GRWR was the same, with a value of 1.1 ± 0.2. All of our cases showed no evidence of steatosis thus showing an accuracy of 100% of CT assessment of steatosis.CT arteriography, portograpy and venography showed no difference in anatomy as compared with the intra-operative date thus showing an accuracy of 100%.Intra-operative cholangiography showed two cases having two right hepatic ducts that were not apparent on pre-operative MRCP thus showing an accuracy of 95%. Conclusion: Sixty-four-row multi-detector CT is a valuable tool in the evaluation of potential living liver donors that provides complete and comprehensive information on the hepatic vascular anatomy, the liver parenchyma, and volumetric measurements. MRC with a 3.0-T MR system demonstrates the preoperative biliary evaluation for living donors very well with a high accuracy rate.