Diabetes mellitus is a disorder characterized by hyperglycemia due to an absolute or relative deficiency of insulin and or insulin resistance. Diabetic patients are prone to long-term complications, such as retinopathy, cataract, atherosclerosis, neuropathy and nephropathy by increasing protein glycation and the gradual build-up of AGEs in body tissues and activation of the RAGE leading to a cascade of pro-inflammatory and pro-coagulant responses which are important in the pathogenesis of the vascular complications of diabetes. This study describes the role of the serum level of sRAGE as well as −374 T/A and −429 T/C polymorphisms in the gene encoding RAGE in the pathogenesis of vascular complications in type 2 diabetes. Serum sRAGE level was found to be higher in both complicated & non-complicated diabetic patients than its level in controls (p= 0.001 & 0.021 respectively) and there was significant association between RAGE -374 T/A & -429 T/C and complicated diabetes (p= 0.030 & 0.043 respectively).