Basic fibroblast growth factor is a major member of the fibroblast growth factor family produced by many cell types. It is one of the major angiogenesis factors and it has a role in normal skin homeostasis, wound healing and tumorigenesis. Although bFGF is synthesized by many cell types, including endothelial cells, keratinocytes and melanocytes, its secretion is poorly understood because it lacks a signal sequence that directs its secretion. Basic fibroblast growth factor is also a known mitogen for keratinocytes and endothelial cells. Our work aims to study the distribution of bFGF in basal cell carcinoma (as an example of malignant skin lesion) and warts (as an example of benign proliferation) and skin tags (as an example of benign skin tumor) in order to detect the role of bFGF and its distribution in these cutaneous lesions. Thirty eight patients were the subject of our study ; thirteen patients with BCC, fifteen patients with warts and ten patients with skin tags. Their clinical data were collected and immunohistochemistry staining of bFGF in their lesional and non-lesional skin biopsies was done. Our results showed that immunohistochemistry staining of the whole epidermis of lesional skin in BCC, warts and skin tags and no staining of normal skin of the same patients. So we concluded that bFGF may have a role in the pathogenesis of these diseases for further assessment and investigations.