Cadmium is a toxic trace metal which arises from batteries electroplating plastic and fertilizer industries. The aim of the present work was to study the effect of cadmium on the live of adult albino rats and to demonstrate the protective role of combined antioxidants (selenium, vitamins a, c and e) for this study adult male albino Wistar rats were divided into there groups control cadmium received group and cadmium supplemented by combined by combined antioxidants (selenium, vitamins a, c and e) received group. Structurally cadmium-received rats demonstrated markedly disturbed hepataic architecture widespread dilatation of the central veins as well as hepatic sinusoid mononuclear cellular infiltration and significant increase in both the Kupffer cells as well as the amount of collagen fibers (using Masson’s trichrome stain) the hepatocytes disphayed hydropic cytoplasmic degeneration and variable nuclear degenerative changes concomitantly there was in the a decrease in the carbohydrate content of these hepatocytes (using pas stain) and significant elevation in serum liver enzymes electron microscopic stuy of the hepatocytes of cadmium-received group revealed marked rarefaction and vacuolation of the cytoplasm with loss of most cell organelles in liver specimens of animals received cadmium supplemented by antioxidants there was a rectifying effect on the studied parameters to variable degrees conclusion cadmium had produced injurious effects to the liver and the use of a combination of antioxidants (selenium, vitamins a, c and e) has a protective effect against these injurious effects.