Keloid represent an overgrowth of dense fibrous tissue. Angiogenesis is a recognized event in Keloid. Vascular endothelial growth factor (VEGF) is a key factor in promoting angiogenesis in the Keloid lesion. In this study 25 patients with Keloid were treated by pulsed-dye laser (PDL). Patients subjected to a 3 laser sessions with one month apart. Laser parameters were: a wavelength of 585 nanometer, fluences of 6.7 Jouls/cm2, pulse durations of short (450 μsec) and spot sizes of 5 millimeter with 50 - 80 % of overlapping. Results showed a clinical response varied from 20 - 100 % (mean 68.3%). Five cases (20%) showed complete (100%) clearance, 4 cases (16%) showed marked (80-95%), 14 cases (56%) had moderate (60%) and the remaining 2 cases (8%) had mild (20-40%) improvement. A difference of high statistical significance was found between the level of VEGF gene in the Keloid lesion before laser therapy than after (P < 0.001). Conclusion: Selective vascular destruction by PDL is an effective treatment modality for cases with Keloid lesion not responsive to other forms of topical therapy or injection.