Beta
39000

Correlation between clinical parameters, blood pressure dipping, highly sensitive CRP plasma level and carotid intima-media thickness in patients with obstructive sleep apnea

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Cardiovascular Diseases

Advisors

Ebrahim, Sulayman G. , El-Tawil, Ahmad E. , Muhammad, Husain H.

Authors

Aly, Nuha Hasanain Muhammad

Accessioned

2017-04-26 12:33:09

Available

2017-04-26 12:33:09

type

M.D. Thesis

Abstract

Background: Mechanisms for linkage between sleep disordered breathing and cardiovascular diseases are not fully determined but surges in sympathetic nerve activity are seen at the end of each apnoeic episode accompanied by large rises in systemic arterial blood pressure.Material & Methods: The study was conducted on 50 patients complaining of snoring and/ or excessive daytime sleepiness assessed by Epworth Sleepiness Scale. All were subjected to sleep study , 24hour ambulatory blood pressure monitoring ,carotid duplex scanning and quantitative determination of high sensitivity C- reactive proteinResults: Patients having apnea hypopnea index (AHI )≥5 diagnosed as apnea group (group I) and those having AHI less than 5 were diagnosed as snorers (group II).Seventy eight percentage of study population were non nocturnal dippers, 81.3% of group I versus 72.2% of group II with non significant p value ( p = 0.494) . Mean diastolic day and night blood pressure, was higher in group I compared to group II with significant p value 0.028 and 0.007 respectively. Mean Carotid intima media thickness (IMT) was significantly higher in group I with p <0.001.Conclusion: Epworth Sleepiness Scale is good reflector of sleep study data. Mean diastolic day and night blood pressure, mean arterial blood pressure are significantly higher in apnea patients. Increased carotid IMT is associated with higher AHI, lower minimum saturation assessed during the sleep study and higher HS- CRP serum level.

Issued

1 Jan 2009

DOI

http://dx.doi.org/10.21473/iknito-space/32944

Details

Type

Thesis

Created At

31 Jan 2023