In diabetes mellitus, oxidized LDL may be an important factor in the process of atherogenesis as well as renal complications. In addition, total homocysteine may also contribute to microvascular complications.The study evaluates the levels of OLAB and total homocysteine in 20 healthy controls and 45 diabetic patients with various degrees of nephropathy and 15 non- diabetic patients with proteinuria . Laboratory investigations included FBS, PPBS, total protein in urine, lipid profile, kidney function tests, glycoHB% , OLAB and total homocysteine. We concluded that OLAB level may not be used as indicator of diabetic nephropathy , however hyperhomocysteinemia in nephropathic patients may indicate its role in renal pathology.