Fluorescence in situ hybredization (FISH) is a powerful Technique for detection of DNA or RNA sequences in cells, tissues and tumors. This molecular cytogenic technique enable the localization of specific DNA sequences within interphase chromatine and metaphase chromosome and identification of both structural and numerical chomosome changes. FISH is becoming one of the most extensively used cytochemical staining technique owing to its sensitivity and versatility (Shao et al, 1997).Fluorescence in situ hybredization (FISH) technique is Now applied in detection of several diseases such as any DNA or RNA abnormalties. It also have benificial role in early detection of tumours as well as have an important role in detection of numerical and structural chromosomal anomalies(Anastasi et al 1992 and 1994)