In our study, we tried to clarify the relationship between NIDDM and gallbladder motor function, and the possible role of obesity and gallstone. Ultrasonography was used to determine gallbladder motor function in response to fatty meal after overnight fasting in 40 obese patients with type II diabetes mellitus (with and without GS), 40 obese non-diabetic patients (with and without GS), and 20 controls (non diabetic non-obese without GS).There was a statistically significant increase in the gallbladder fasting volume (FV) considering addition of risk factor as diabetes, obesity and gallstone. FV in control group was (17.38+/-3.10), when we added obesity factor it was (26.40+/-6.50). When gallstone factor was added FV was (31.30+/-5.50) and when the patients had diabetes, it was (39.30+/-9.40).The ejection fraction showed a statistically significant decrease considering the addition of risk factor as diabetes, obesity and gallstone. EF in control group was (76%+/-5%), when we added obesity factor it was (53%+/-5%). When gallstone factor was added EF was (47%+/-5%) and when the patients had diabetes, it was (40%+/-5%).