Cryoglobulins are immunoglobulins or immune complexes which precipitate at a temperature lower than 37°C and redissolve when rewarmed. Clinical features of cryoglobulinemia are in most cases cutaneous, renal, neurological or could be asymptomatic Cryoglobulinemia can be also associated with malignant haematological disorder, connective tissue disease or infection process especially infection with hepatitis C virus. The prevalence of anti-HCV among dialysis patients varies in different countries (5-85%) worldwide, and may exceed 95% in the Middle East. Since the prevalence of HCV infection in patients on HD is reported to be very high, the incidence of MC is also expected to be high in this patient population.Objective: The aim of this study is to evaluate the prevalence of cryoglobulinemia among patients with chronic renal failure undergoing regular haemodialysis.Methods : In this study , forty patients with chronic renal failure receiving regular haemodialysis sessions ( three sessions / week) regardless of their hepatitis C virus infection status( infected or not). The patients will be subdivided into 2 groups:- These patients were subjected to the following investigation :- S.BUN , s. creatinine , s. Na, s. K, ALT, AST, s. Ca ,s. Po4, s. albumin, test for cryoglobulin detection, hepatitis C virus antibodies, RF, INR, Platelets, Hb%Results and conclusion: This study revealed incidence of cryoglobulinemia (12.5%) in patients on regular HD and the incidence of cryoglobulinemia in hepatitis C postive on regular HD was (20%) higher than in hepatitis C negative , it was only 5% .RF activity positivity (40%) in HD cryopositive patients The symptoms of cryoglobulinemia (purpura, arthralgia & generalized weakness) appear more frequently in cryoglobulin positive patients and hepatitis C postive patients.AST was found to be significant predictor for cryopositivty in HD patients.