Objective: to compare the sexual function of women with female genital mutilation (FGM) to women without FGM.Setting: outpatient clinic of gynecology and obstetrics at Kasr El Aini University Hospitals School of Medicine, Cairo University.Patients: two hundred sexually active women with FGM and one hundred sexually active women without FGM.Tools: women with and without FGM were asked to answer the Arabic-translated version of the female sexual function index (FSFI) questionnaire.Main Outcome measures: the individual domain scores for arousal, lubrication and orgasm.Results: the 2 groups were comparable in demographic characteristics. There were no statistically significant differences between the 2 groups in means of lubrication score (p>0.415). However, there were statistically significant differences between the 2 groups in their scores for sexual arousal and orgasm (p<0.001).Conclusion: sexual function in women with FGM is adversely altered. This adds to the well-known health consequences of FGM. Efforts to document these complications should be encouraged so that FGM can be abandoned.