Background: Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Alterations of the insulin-like growth factor (IGF) system have been demonstrated in different hematological and solid malignancies and provide a potential target for novel anticancer therapies. Aim Of The Study: Evaluating the expression of human insulin-like growth factor binding protein 2 and 7 (IGFBP2 and IGFBP7), as new candidate genes implicated in leukemia and correlating the results with the different clinical and laboratory findings of the patients. Subjects and Methods: The study included 35newly diagnosed adult AML patients and 20 age and sex comparable healthy controls. Detection of IGFBP2 and IGFBP7 genes is done using real time RT-PCR. Results: We found significant association between both genes and overall survival of AML patients. CONCLUSION: High expression of both genes was associated with poor prognosis in AML cases.