Iron deficiency anemia (IDA) is major and prevalent problems in Egypt. The differentiation between Iron deficiency Anaemia (IDA) and Anemia of Chronic Diseases (ACD) is often troublesome. This study was undertaken to evaluate the ability of soluble transferring Receptors sTfR in categorizing different types of anemia in children. The results of the study showed a significant increase in the mean levels of sTfR in the (IDA) group when compared to the controls. Meanwhile, there was a significant decrease in mean levels of sTfR in (ACD) group as compared to the control group.