Augmentation of labor with high-dose oxytocinprotocol, is associated with a lower rate of cesarean delivery andshorter duration of labor than that usually found in the low-doseprotocol. We conducted a randomized trial to compare the efficacyand safety of both approachs among women delivering their babies. We randomly assigned 40 nulliparous and multiparouswomen at low risk of complications of pregnancy, to activemanagement of labor with high-dose oxytocin protocol or to a low-doseoxytocin protocol. The components of active management ; strict criteria for the diagnosis of labor ; standardized management of labor,including early amniotomy and treatment with high-dose oxytocin orlow-dose oxytocin; and one-to-one nursing. There was no difference between the two groups in the rateof cesarean section and the median duration of labor. There was nosignificant increase in neonatal complications in the high-dose oxytocingroup, and no difference in the values of neonatal umbilical arterialblood gas analysis between the two groups. The use of high-dose oxytocin regimen in laboraugmentation is completely safe which may associated with mildrespiratory acidosis with excellent prognosis as regard neonataloutcome, but did not reduce the rate of cesarean section norassociated with shorter duration of labor, as compared with the lowdose regimen.