Psoriasis vulgaris is a skin disease characterized byhyperproliferation of epidermal keratinocytes, capillary elongation,accompanied by inflammatory cell infiltrate. Keratinocyteshyperproliferation could be explained by dysregulation of growthfactors controlling epidermal proliferation and by altered metabolismof their receptors in affected skin.Transforming growth factor beta 1 regulates the proliferation anddifferentiation of cells, wound healing, and angiogenesis. It is apotent inhibitor of cells as it arrests the cell cycle in the G1 to Sphases. It shows a multitude of effects on cellular differentiation andgrowth.