This study shown that lactate reduction during the first 24 hours of ICU stay is associated with improved outcome only in septic patients, but not in patients with hemorrhage or other conditions generally associated with low-oxygen transport, regardless of the haemodynamic status. There were no statistically significant differences between studied groups regarding survival rate despite higher survival rate in septic group (75% of patients) than low oxygen transport group (50% of patients) due to decreased sample size as 40 patients only were encluded.Regarding non survivors were higher in low-oxygen transport group than septic group in patients with age adjustment less than 45 years old, with statistically significant P-value (0.05). On the other hand non survivors were higher in septic group than low-oxygen transport group in patients with age adjustment ≥ 55 years with high statistical significant P-value (0.002).