Asthma is a complex multifactorial disease with an obvious geneticpredisposition. Polymorphisms of the glutathione-S-transferase (GST) genes areknown risk factors for some environmentally related diseases. The aim of thepresent study was to investigate the role of polymorphisms in the GSTT1andGSTM1 genes and asthma susceptibility in Egyptian children.We assessed GSTT1 and GSTM1 profile in a group of Egyptianasthmatic infants and children through screening of genetic polymorphism ofGST with special emphasis on the relation of measured parameters to differentclinical (severity, family history, other atopic manifestations) and laboratorydata (IgE-peripheral blood eosinophil count) and pulmonary function tests.Ninety four asthmatic Children aged 6yr to 12yr and matched control group of90 children were recruited for the present study.The genotype analysis of patients and controls revealed a no significantstatistical difference in the expression of the different genotypes between bothof them. In conclusion, GSTT1 and GSTM1 polymorphisms are not associatedwith risk of developing asthma in children.