Background: Pemphigus vulgaris (PV) is an autoimmune bullousdisorder involving the skin and mucous epithelia. The role of nutritionalfactors in PV has been proved by epidemiological, clinical, andlaboratory data.Aim of the study: To investigate the serum levels of zinc and copper astwo important trace elements in patients with pemphigus vulgaris (PV).Materials and methods: This a prospective investigational study,including 25 patients with newly diagnosed PV and 25 age and sexmatched healthy control subjects. In both groups, serum concentrations ofzinc, copper and ceruloplasmin were estimated. Zinc and Copper weremeasured by spectrophotometry and ceruloplasmin was measured byradial immunodiffusionResults: The results of our study revealed that all PV patients had astatistically significant lower serum zinc (P< .003), copper (P< .016) andceruloplasmin levels (P< .01) when compared with healthy controls. Anegative, but statistically insignificant, correlation was detected betweenserum zinc level and disease duration. A statistically significant negativecorrelation was found between serum zinc level and the disease severity.Conclusion: The longer the PV disease duration and the more severe thedisease, the lower the serum zinc level. Trace element supplementation inPV patients should be considered essential, may be even mandatory tocorrect the drop in serum levels of Zinc, Copper and Ceruloplasmin. Itmay alleviate the disease severity and mortality, but it needs longerstudies on more patients to confirm this postulation.