Our study was conducted on 40 neonates. Their gestational age range of between 37-40 weeks. They were divided into 3 groups: (1) AGA: 10 neonates control group; (2) LGA: 15 neonates; (3) SGA: 15 neonates. All groups were subjected to estimation of insulin level and IGF-I in cord blood. We found that insulin and IGF-I were significantly & higher level in LGA group compared to AGA group. A positive correlation was found between IGF-I, birth weight, length and gestational age. There was also a positive correlation between cord blood insulin and IGF-I.