Polycystic ovarian syndrome is one of the most common gynecological endocrine disorders. The most accepted definition of PCO would be eugonadotropic hyperandrogenic anovulation with the presence of multiple small ovarian follicles. The clinical presentation varies between menstrual disturbances in the form of oligomenorrhea or amenorrhea, infertility due to anovulation, obesity and insulin resistance. Clomiphene citrate induces ovulation in approximately of 70-85% PCO patients. Patients with clomiphene citrate resistant polycystic ovarian syndrome are offered various treatment modalities like naltrexone. Form our study we concluded that ovulation can be induced successfully using naltrexone in combination with clomiphene citrate.