Objective : The aim of this study was to elevate the sensitivity of CT colonography in detection of colorectal polyps & neoplastic lesions.Materials and Methods: Patients referred for standard colonoscopy between February 2001 and October 2004 for colorectal cancer screening or for evaluation of colorectal symptoms were invited to undergo CT colonography on the same. Day. Seventy-one patients were recruited for study "44 males ; 27 females " their ago ranges from 11 – 80 years with a mean ago of " 49.4 years" Twenty patients "11 males ; 9 females " had no colonic abnormality by fibro-optic or virtual colonoscopic examinations and were considered to be the control group. Results : The results showed that the sensitivity of polyp detection increases remarkable with advancement of polyp size . The sensitivity in detection of small "<5mm" polyp was 60% while in medium sized polyps was 92% & for large polyp was 98%. Virtual colonoscopy showed 100% sensitivity for detection of strictures and mass lesions.Conclusion : Virtual colonoscopy is a simple, reliable, cheaper, highly acceptable and sensitive examination. It requires no sedation and has no significant perforation risk. It detect the exact anatomical site of the colonic lesion. It allows 3D viewing of the colon in a forward and reverse detection. It allows complete abdomino-pelvic assessment of the extra colonic organs. It can assess the colon proximal to an occlusive stenotic lesion even those impassable by the conventional Colonoscopy.