Background: Cardiovascular disease (CVD) is the leading cause of death in people with type 1 diabetes mellitus (T1DM). Dyslipidemia is a significant CVD risk factor in persons with diabetes. Measurement of apoA-1 in diabetic patients may be helpful to diabetic patients at risk of cardiovascular diseases.Objective: To assess the level of Apo A-1 in dyslipidemic type 1 diabetic children in Diabetic Endocrine Metabolic Pediatric Unit (DEMPU). Methods: This case control study was conducted on 40 patients with T1DM and 28 healthy controls. Patients were evaluated clinically by full history taking and thorough clinical examination. Full history includes; chronological age of the patient, age at the onset of diabetes, duration of diabetes, insulin therapy and family history of diabetes mellitus, hypertension and dyslipidemia. Thorough clinical examination laying stress on the anthropometric measurements, early signs of puberty and signs of associated disorders &/or diabetic chronic complications. The records of the patients reviewed especially for the mean of HbA1c done in the last year, presence of diabetic retinopathy or microalbuminuria. We measured Apo A1 for all subjects included in the study.Results: plasma levels of apoA-1 in diabetic patients (2.774±0.559 g/L) are significantly higher than healthy children (2.506± 0.459 g/L), and that, serum total cholesterol in the diabetic group is significantly higher than in control group (182.50±39.868 mg/dl Vs 149.07±24.375 mg/dl) & serum LDL in the diabetic group is significantly higher than in control group (116.12 ± 32.589 mg/dl Vs 84.04 ± 19.234 mg/dl). Furthermore, there was no significant correlation between serum Apo A-1 and (anthropometric measures, duration of diabetes, serum HDL, serum TG, HbA1C % and insulin dose).Conclusion: Plasma levels of apoA-1 are higher in the dyslipidemic type 1 diabetic children than healthy childrens. Therefore, assessment of Apo A-1 may be useful especially when patients have a personal or family history of dyslipidemia.