Tuberculosis, one of the commonest human infections, responsible for 26% of preventable deaths in the developing nations as estimated by WHO. There are a number of possible reasons for this increase comprising deterioration in living conditions, and spread of HIV infections that is often due to reactivation rather than primary infection. A major problem in these cases is the emergence of resistance to several anti-tuberculosis drugs. The impact is to study the effect of anti-tuberculosis therapy used on the levels of immunoglobulins (IgG, IgA, and IgM) in fresh patients receiving 2-3 months multi-drug regimen. We conclude that the evaluation of IgA- mediated humoral immune response might constitute a useful tool not only for presumptive diagnosis of pulmonary TB, but also for justification of r4esponse to therapy.