The benefit of radiotherapy alone, in inoperable patients, or in combination with surgery, has been demonstrated in several phase III trials. In order to improve the outcome, multiple combinations of surgery, radiotherapy and chemotherapy have been evaluated in several studies there are ongoing trials to evaluate combination of TMZ with other chemotherapeutic drugs and targeted agents in the term of response rate, median survival and progression free survival hoping to improve the outcome in patients with glioblastoma multiforme.Our study was designed to randomize patients either to receive the standard treatment including radiotherapy concomitant with TMZ followed by 6 months of adjuvant TMZ versus radiotherapy concomitant with TMZ followed by observation, aiming at minimizing the cost of the treatment without interfering with the benefit of the patient and also avoiding the adjuvant treatment related toxicity