Background: Carotid intima media thickness (CIMT) may have clinical application as a marker of atherosclerosis development in the setting of various risk factors. Objective: We aimed to investigate the effects of age, sex, obesity and smoking on the Carotid Intima Media Thickness (IMT) in a sample of normal Egyptian subjects. Subjects and methods: The study included 101 normal healthy Egyptian subjects, who underwent duplex ultrasonography of the carotid arteries for assessment of the IMT. Results: Statistically highly significant differences between subjects of different ages and average carotid IMT. Mean average CIMT was significantly thicker in males compared to females. Mean smoking duration showed highly significant positive correlation with carotid IMT. Multivariate analysis showed that age, smoking and interaction of age with smoking were the only independent factors affecting carotid IMT. After regression analysis age was found to be the significant predictor for carotid IMT in both male and female subjects. In Conclusion: Age was the significant predictor for CIMT in normal Egyptian subjects. Smoking and interaction of age with smoking were also independent factors affecting carotid IMT in normal Egyptians.