This study was conducted to evaluate the effects of 7 days treatment with midodrine, an alpha 1-agonist, in non azotemic cirrhotic patients with tense ascites. Midodrine group: (Patients subjected to Midodrine and Diuretics) shows a significant decrease in body weight and a significant increase in B.U.N. at the end of the 7 days study compared to day 1 of the study. Control group: (Patients subjected to Diuretics) shows a significant decrease in body weight at the end of the 7 days study compared to day 1 of the study. In a comparison between the above two groups There was a significant increase in urine output and a significant decrease in serum creatinine in patients of Midodrine group as compared with patients of Control group. So, the present study shows that administration of Midodrine with diuretics in patients with tense ascites led to a significant diuresis as well as a significant improvement of renal functions as compared to patients who were administered diuretics only.