Autism is a neurodevelopmental disorder characterized by severe impairment of socialization, communication and patterns of repetitive behaviors. Individuals with autism exhibit abnormal auditory processing that affects their ability to comprehend social cues and to learn language. There is evidence of the efficacy of directed auditory training for improving auditory processing in a population of children with autism by impacting biological processes. A computerized audiovisual-based training program (Let’s Learn) focusing on enhancing auditory skills in Egyptian children with autism was designed, the program can be used in conjunction with traditional lines of therapy in order to help children with autism develop their language and communication skills in a functional manner. After the application of Let’s Learn on 20 autistic children for 10 weeks together with the ordinary rehabilitation program for autism, the progress achieved with therapy was compared to another 20 autistic children who had received ordinary rehabilitation program only. This comparison showed significant improvement in: eye contact, attention, response latency and activity level which are essential prerequisites for improvement of joint attention and language acquisition in those children.The application of Let’s Learn for a sufficient duration is thus expected to have positive impact on language acquisition and development of communication skills in these children.