Vancomycin, a glycopeptide antibiotic, is commonly used in recent years against methicillin-resistant gram-positive bacteria, due to the rising incidence of infections caused by methicillin-resistant staphylococcus aureus and staphylococcus epidermidis The aim of the present work was to investigate the histological and histomorphometric changes in the kidneys of adult male albino rats following vancomycin administration and to study the possible protective role of vitamin E against vancomycin-induced nephrotoxicity.