Introduction: cardiovascular diseases (CVD) are among prevalent and preventable of all health problems, resulting in decreased quality of life for millions of people. Unfortunately, developing countries suffer the most, As for Egypt ,CVD, particularly rheumatic heat disease is a significant health problem. Youth represent a priority group. Internationally, there is extensive research assessing the QOL of CVD patients, but there is a lack of such studies among the youth age group. This also applies on a local scale in Egypt.Objective: of the study include an investigation the epidemiological profile of cardiovascular disease among the studied group of youth, a Quality of lifeAssessment of the cases compared with the controls, and a study of the possible determinants showing a significant association with QOL. And finally development of an Egyptian HRQL model to predict QOL among cardiovascular diseased youth.Subject & Methods: an analytic case control study that involved 500 patents and 500 apparently health controls. Age range 18-24 years , was performed in the cardiology department of the kasr el aini Hospital as well as the national heat institute. All cases and control were subject to a generic QOL tool ( i.e the SF-36v.2) and a disease specific tool (MacNew Heart Disease HRQL questionnaire) was used to study QOL among the rheumatic heat disease group.Results:The results of this study can be divided into following sections: background Characteristics of the studied groups: epidemiologic profile of the cases: quality of life(QOL)summary of all study group: determinants of QOL among the cases and qualitative analysis of patient interviews.Conclusion & Recommendations:The study results showed that cardiovascular diseases have a negative impact on almost all aspects of the quality of life of diseased youth when compared to their healthy counterparts. Furthermore, RHD scored higher QOL than those with other CVDs. The study recommended establishing comprehensive strategies to improve their quality of life that follow four paths simultaneously : prevention, Treatment, Rehabilitation, and further Research.