Diffusion-weighted magnetic resonance (MR) imaging is a technique that has traditionally been used in neuroimaging for the detection of acute ischemia and other intracranial disease. Recently, diffusion-weighted imaging (DWI) has emerged as a diagnostic technique in the evaluation of various abdominal lesions. (Chow et al., 2005).The MR signal at diffusion-weighted imaging depends on two factors: the amplitude of random displacements of water molecules (related to the ADC value) and, to a lesser extent, the b value (degree of diffusion weighting). The b value is determined on the basis of the strength and duration of the paired gradients and the time interval between their respective applications. In clinical diffusion-weighted MR imaging, the b value is generally altered by changing the strength of the diffusion gradients.( Koh and Collins, 2007).The apparent diffusion coefficent (ADC) value has been reported to be useful for quantitatively distinguishing malignancy from benign lesions. The cause of a decrease of the ADC values is considered to be that malignancies commonly have a larger cell diameter and denser cellularity than normal tissue, which restrict water diffusion. (Chow et al., 2005).With continuing improvement in the quality of body MR imaging sequences, single-shot T2- weighted and three-dimensional unenhanced and contrast-enhanced T1-weighted gradient-echo sequences have been successfully used to characterize cystic and solid lesions of the pancreas.(Wang et al.,2011)Diffusion-weighted MR imaging has also been used to characterize pancreatic lesions in various pathologic entities.(Wang et al.,2011)Because of overlap of imaging features, it is difficult to differentiate between mass-forming focal pancreatitis and pancreatic adenocarcinoma with standard cross-sectional imaging techniques, including computed tomography (CT) and conventional MR imaging. (Wang et al., 2011) The use of diffusion-weighted imaging may allow earlier detection of pancreatic adenocarcinoma, since these neoplasms have increased signal intensity on diffusion-weighted images with high b values (b > 500 sec/mm2) and relatively low ADC values because of the restricted diffusion associated with fibrosis.(Wang et al., 2011).