Observational study was conducted to determine the Incidence and relative frequency of congenital heart disease diagnosed by echocardiography Unit in pediatric Hospital, Cairo University Children Hospital (CUCH) over a period of 1 year (1 January 2013- 31 December 2013).Congenital heart diseases were the most frequent cardiac abnormalities (41.9%). Majority of the cases (69.7%) were Acyanotic, remaining (30.3%) were cyanotic. Among the Acyanotic VSD (14.87 %*) was the commonest 2nd was ASD (13.98 %*) while in acyanotic group D-TGA (6.65 %*) was the commonest followed by TOF (6.43 %*). Male preponderance, the most clinical presentation was Breathlessness and poor weight gain, majority of case was sever CHD are important observation made in the study.