Homocysteine (Hcy) is an intermediate sulpur-containing amino acid formed during methionine metabolism.A strong correlation between Hcy levels and diabetes has been found. Elevated plasma levels of homocysteine in type 2 diabetes are associated with a higher prevalence of peripheral arteriopathy and diabetic nephropathy. Hyperhomocysteinemia is not associated with fat mass but it is associated with high levels of fibrinogen, lipoprotein (a), microalbuminuria, and blood pressure levels. Homocysteine might be associated with longer diabetic duration and microvascular complication of retinopathy in diabetes. The slight rise in homocysteine levels in patients with diabetic retinopathy was possibly caused by the early nephropathy as indicated by microalbuminuria