Objectives : Assessment of progesterone receptor expression inastrocytomas in a group of Egyptian patients and evaluation of it'sexpression in relation to the tumour proliferative potential as assessed byKi-67 labeling index.Material and Methods : Forty cases of astorcytic gliomas were collectedand assessed for tumor type, grade , progesterone receptor expression andki-67 labeling index.Results : Among the studied sample, 10% of cases were pilocytic type,20% Diffuse type, 27.5% Anaplastic type and 42.5% GlioblastomaMultiforme. PR was positively expressed in 45% of cases and wascorrelated significantly with high grade tumours. Twenty one cases(52.9%) showed a low ki-67 LI while 19 cases (47.5%) showed high ki-67 LI. PR positive tumours had significantly higher mean ki-67 LI(33.5%) compared with PR negative tumours (13.2%).Conclusions and Recommendations :Astrocytic tumours express progesterone receptorimmunoreactivity with a direct correlation between PR expression andtumour grade. Also, PR positive astrocytic tumours possess a higherproliferative potential than PR negative tumours. Further study is neededto clarify the role of PR in astrocytic tumour recurrence and patientsurvival. Additional studies are needed to clarify the role of sex steroidsin brain tumour growth and development.