Assessment of quality of life in multiple sclerosis using functional assessment scale of MS {FAMS } , disability & impacts profile {DIP } in parallel with extended disability status scale { EDSS } applied on 31 Egyptian patient their ages { 20-54y} already diagnosed as definite MS , all patient applied for full neurological examination &the three previous scales. The results statistically analyzed which show strong relation between FAMS { mobility } & EDSS also fife items of DIP shows affection of quality of life.