The effects of TCA (35%) & GA (70 %) on rat skin were evaluated & compared using light microscopy& immunohistochemichal technique. Skin biopsies were taken from the dorsal side of rats (n=40, 5 groups) one & three weeks after peeling session. Sections were stained with hematoxylin and eosin, Masson's trichrome, orcein and immunohistochemichal stain for CD34. The epidermal thicknesses, dermal thickness, mean area percent of collagen& elastic fibers and mean area percent & optical density of immunopositive cells were done. There were increases in epidermal &dermal thickness, reorganization of the dermal structural elements, collagen, and elastic fibres and increase in CD34 immunopositive cells at the end of the third week with statistically non significant difference between the two peeling agents.