Obesity, and especially visceral adipose tissues accumulations, increased the risk of developing type 2 diabetes. Adipose tissues can function as an active endocrine organ, co-regulating whole-body metabolisms through released of many hormones one of them is adiponectin. Circulating plasma adiponectin concentrations have been reported to be reduced in the obese state. The present study compared plasma glucose concentration, adiponectin and CRP between obese & non obese type 2 diabetic patients versus non obese normoglycemic controls .A total of 60 subjects were selected to participate in this study;20 non-obese type 2 diabetes 20 obese type 2 diabetic patients and 20 healthy control subjects . Furthermore, plasma adiponectin levels were significantly lower in the obese versus non-obese diabetes patients . Significant correlations between plasma parameters and adiponectin were observed as it showed indirect significant relationship between adiponectin with BMI, Cholesterol, LDL and TG among all diabetic cases and all groups together.