Modern trends in prenatal diagnosis of fetal anomalies is divided in to non-invasive methods for diagnosis of fetal anomalies which include diagnosis of fetal anomalies by 2d sonography, diagnosis of fetal anomalies by 3d and 4d sonography, magnetic resonance imaging, maternal serum markers, invasive diagnosis of fetal anomalies and amniocentesis chorionic biopsy cordocentesis fetal cells in maternal blood pre implantation genetic diagnosis