Post-operative infections at the site of surgery are common and are one of the main nosocomial causes of complications that increase medical costs, morbidity, and even mortality. So the prevention of surgical site infection remains a focus of attention because wound infections continue to be a major source of expense.The incidence of infection increases with the type of operation from clean, clean contaminated, contaminated and dirty operations respectively.Antimicrobial prophylaxis is used to reduce the incidence of postoperative wound infections. Laparoscopic cholecystectomy, after rapidly substituting traditional cholecystectomy, represented the gold standard for surgical treatment of gall stones.Compared with open cholecystectomy (OC), laparoscopic cholecystectomy LC is associated with lower postoperative infections, which make the role of routine antibiotic prophylaxis (ABP) in this minimally invasive clean contaminated procedure debatable.This study aimed to evaluate the role of prophylactic antibiotics in minimizing surgical site infection mainly in laparocopic cholecystectomy comparing between single preoperative dose versus the traditional three doses; comparing them with patients operated upon without any antibiotics.