Heart Failure is a devastating disease with increasing mortality within 5 years of diagnosis.In an effort to better diagnose HF, intense research has led to the discovery of many potential biomarkers for this debilitating disease.Valuable biomarkers that may be used for prediction, prognosis and diagnosis of HF will be discussed.These biomarkers include natriuretic peptides, cardenolides, cytokine & adrenomedullin.Brain natriuretic peptides emerge as the superior diagnostic and prognostic marker.The concept of using a combination of multiple markers based on diagnosis, prognosis, and acute vs. chronic disease is discussed.Specific immunometric assays with acceptable precision and without need for plasma extraction are already commercially available such as IRMA, ELISA and ECL Abbreviations: HF: Heart Failure, IRMA: Immuno radiometric assay, ELISA: Enzyme-linked immuno sorbant assay, ECL: Electro chemiluminescence