The aim of this study was to establish whether hydration with fluid intake following radiopharmaceutical administration [Tc-99m MDP] has a real impact on the quality of skeletal scintigraphy. A hundred and forty three patients referred for bone scanning for various reasons over a seven month period were classified into two groups. Group 1 was issued with instructions to hydrate properly by fluid intake following tracer injection while subjects of group 2 were instructed not to take any fluids till the scan imaging. Computer based equal regions of interest (ROI) were done; over the mid- femoral diaphysis [bone ROI] and the adjacent soft tissue area [soft tissue ROI]. A bone to soft tissue ratio was obtained for each case [B: ST]. No statistically significant difference was found between the ratios’ means in both groups. Hence, we concluded that hydration with fluids following Tc-99m MDP injection has no significant effect on the bone: soft tissue ratio and in turn, the skeletal scintigraphic quality.