Hormone replacement therapy is used in relieving of menopausal symptoms and other estrogen deficiency states .HRT may be in the form of either estrogen alone ,combined estrogen and progesterone or combined estrogen and androgen. Inspite of, the benefits of HRT, there are certain risks such as endometrial carcinoma , breast cancer and liver disease. Nowadays, there is more interest for update of HRT, concerning SERMS, and Phytoestrogens are to gain the benefits of HRT, and to avoid their side effects, precautions, and contraindications.