Background: Allergic rhinitis is a chronic inflammatory disorder of the nose. Although it is not a life-threatening condition, it has been documented to have a significant impact on quality of life. Methods: This study passed through two phases, the 1st phase was a cross sectional descriptive study to estimate the magnitude of AR. The 2nd Phase was a prospective interventional study conducted to the cohort of AR patients to compare the effect of therapeutic patient education on their HRQoL through the RQLQ(S). The patients were randomly divided into two groups where Group (A) received both pharmacological treatment and patient education while Group (B) received pharmacological treatment alone. RQLQ(S) was assessed for both groups pre and post intervention. Results: Our study was conducted over 845 patients who were screened for AR using the SFAR resulted in 200 AR patients with a prevalence of 23.7%. In the pre-interventional phase, Group (B) scored a higher global RQLQ(S) score (4.0 ± 0.8) compared to the group (A) (3.85 ± 0.8). In the post-interventional phase, the global mean score showed statistical significant difference between both groups with better score to the group (A) 3.38 ± 0.68 while group (B) 3.66 ± 0.55. RQLQ(S) means showed improvement in almost all domains with upper hand to Group (A) in six domains except for the eye symptoms domain which showed more improvement in the Group (B) but with no statistical significance. Conclusion: Providing structured patient education on AR as an intervention has improved the patients scores in RQLQ(S) more than the pharmacological treatment alone.