Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. It stimulates endothelial cell proliferation and induces angiogenesis. We examined the levels of sputum VEGF in 34 asthmatic children (10 in acute exacerbation and 24 during remission) and in 15 non asthmatic children (controls). Higher levels of VEGF were found in asthmatic patients than normal controls and in acute exacerbation than during remission. Also, there is association between the sputum VEGF levels and the severity of asthma. So VEGF has a role in airway remodeling in asthmatic children. Also, VEGF might have a potential role as a therapeutic target in asthma management.